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Table 2 Pre-term outcome overall and for HIV + ve only

From: Improved pregnancy outcomes with increasing antiretroviral coverage in South Africa

All women     Bivariate Multivariable iv  
Variable Term n (% i) Pre-term <37w) n (%) p-value ii 0R iii (95 % CI) 0R (95 % CI) adj p-value
Year       
 2011 3409 (78.03) 960 (21.97) 0.002 1 (ref) 1 (ref)  
 2014 4412 (80.54) 1066 (19.46) 0.86 (0.78–0.95) 0.94 (0.83–1.06) 0.291
Age Category       
  < 18 643 (77.75) 184 (22.25) 0.053 1 (ref) 1 (ref)  
 18–24 3421 (78.54) 935 (21.46) 0.96 (0.8–1.14) 0.92 (0.77–1.1) 0.362
 25–34 2945 (80.42) 717 (19.58) 0.85 (0.71–1.02) 0.78 (0.64–0.94) 0.01
  > 34 726 (81.3) 167 (18.7) 0.8 (0.64–1.02) 0.73 (0.57–0.93) 0.012
Mode of Delivery       
 Vaginal 5365 (80.27) 1319 (19.73) <0.001 1 (ref) 1 (ref)  
 Emergency Caesarean 1100 (75.5) 357 (24.5) 1.32 (1.15–1.51) 1.3 (1.12–1.51) 0.001
 Planned Caesarean 1346 (79.69) 343 (20.31) 1.04 (0.91–1.18) 1.07 (0.93–1.24) 0.319
HIV       
 Negative 4820 (81.47) 1096 (18.53) <0.001 1 (ref) 1 (ref)  
 Positive 2893 (77.71) 830 (22.29) 1.26 (1.14–1.4) 1.33 (1.19–1.48) <0.001
 Unregistered Antenatal 102 (51) 98 (49) 4.23 (3.18–5.62) 4.24 (3.18–5.64) <0.001
HIV + ve women only     Bivariate Multivariable v  
Variable Term n (% i) Pre-term (<37w) n (%) p-value ii 0R (95 % CI) 0R (95 % CI) adj p-value
Year       
 2011 1249 (77.19) 369 (22.81) 0.51 1 (ref) 1 (ref)  
 2014 1644 (78.1) 461 (21.9) 0.95 (0.81–1.11) 0.63 (0.27–1.44) 0.269
Age Category       
  < 18 69 (74.19) 24 (25.81) 0.849 1 (ref) 1 (ref)  
 18–24 925 (77.8) 264 (22.2) 0.82 (0.51–1.33) 1.14 (0.32–4.01) 0.84
 25–34 1482 (77.88) 421 (22.12) 0.82 (0.51–1.32) 1.26 (0.36–4.4) 0.717
  > 34 395 (78.37) 109 (21.63) 0.79 (0.48–1.32) 1.35 (0.36–5) 0.655
Mode of Delivery       
 Vaginal 1940 (78.51) 531 (21.49) 0.13 1 (ref) 1 (ref)  
 Emergency Caesarean 420 (74.6) 143 (25.4) 1.24 (1.01–1.54) 1.43 (1–2.06) 0.05
 Planned Caesarean 526 (77.47) 153 (22.53) 1.06 (0.87–1.3) 0.82 (0.49–1.37) 0.456
CD4 category       
  < 200 274 (80.35) 67 (19.65) 0.582 1 (ref) 1 (ref)  
 201–350 282 (82.22) 61 (17.78) 0.88 (0.6–1.3) 0.87 (0.58–1.29) 0.478
 351–500 275 (81.36) 63 (18.64) 0.94 (0.64–1.37) 0.92 (0.6–1.39) 0.686
  > 500 136 (77.27) 40 (22.73) 1.2 (0.77–1.87) 1.16 (0.72–1.88) 0.545
ART regimen       
 Nil ARVs 100 (67.57) 48 (32.43) 0.002 1 (ref) 1 (ref)  
 AZT/NVP 778 (79.88) 196 (20.12) 0.52 (0.36–0.77) 0.2 (0.08–0.51) 0.001
 D4T/3TC/NVP 685 (75.52) 222 (24.48) 0.68 (0.46–0.98) 0.21 (0.08–0.55) 0.001
 EFV/TDF/FTC 1315 (78.93) 351 (21.07) 0.56 (0.39–0.8) 0.31 (0.11–0.9) 0.031
  1. i row percentage, ii Chi-square, iii Odds Ratio, iv following variables were adjusted for in the multivariable adjusted model, year age group, mode of delivery, pregnancy term category, HIV status
  2. i Chi-square, ii AZT/NVP vs D4T/3TC/NVP p-value = 0.714, iii AZT/NVP vs FTC p-value = 0.321, iv D4T/3TC/NVP vs FTC p-value = 0.368, v following variables were adjusted for in the multivariable adjusted model, year age group, mode of delivery, pregnancy term category, HIV status, CD4 (HIV positive mothers only), ART regimen (HIV positive mothers only)