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Table 2 Characteristics of the study population according to the occurrence of delivery within 48 h

From: Plasma inflammatory and immune proteins as predictors of intra-amniotic infection and spontaneous preterm delivery in women with preterm labor: a retrospective study

  Spontaneous preterm delivery after sampling P-value
≤48 h (n = 26) > 48 h (n = 147)
Maternal age (years) 33.0 ± 4.0 31.3 ± 4.0 0.047
Nulliparity 35% (9) 66% (97) 0.003
Gestational age at sampling (weeks) 30.7 ± 2.6 30.0 ± 2.7 0.195
Gestational age at delivery (weeks) 30.7 ± 2.5 36.1 ± 4.0 <  0.001
Serum C-reactive protein (mg/L) 14.3 ± 15.2 8.2 ± 13.4 0.003
Cervical length on ultrasonography (mm) 13.8 ± 10.9 26.7 ± 11.1 < 0.001
Plasma C3a (μg/mL) 12.9 ± 7.9 12.9 ± 7.7 0.863
Plasma C5a (ng/mL) 41.0 ± 14.0 45.6 ± 12.5 0.237
Plasma interleukin-6 (pg/mL) 11.7 ± 12.0 4.0 ± 4.2 < 0.001
Plasma matrix metalloproteinase-9 (ng/mL) 251.0 ± 253.9 207.6 ± 175.9 0.858
Use of tocolytic agents 89% (23) 95% (139) 0.242
Use of antibiotics 27% (7) 31% (45) 0.706
Use of antenatal corticosteroids 89% (23) 76% (112) 0.165
Clinical chorioamnionitis 3.8% (1) 0% (0) 0.017
Histological chorioamnionitisa 50% (13/26) 35% (26/75) 0.169
Positive amniotic fluid cultures 19% (5) 7.5% (11) 0.057
Amniotic fluid interleukin-6 (ng/mL) 11.7 ± 21.4 2.8 ± 8.9 < 0.001
  1. Data are given as mean ± standard deviation or % (n/N)
  2. aData for the histologic evaluation of the placenta were only available for 101 of the 173 women because delivery took place at another institution in 5 cases, and histologic evaluation of the placenta was not performed in 67 cases because of our institutional policy that only the placentas from preterm deliveries are sent for histopathologic examination