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Table 4 Diagnostic indices of various factors to predict intra-amniotic infection and imminent preterm delivery

From: Plasma inflammatory and immune proteins as predictors of intra-amniotic infection and spontaneous preterm delivery in women with preterm labor: a retrospective study

Variables Area (±SE) under the ROC curve 95% CI Cut-off valuea Sensitivityb (95% CI) Specificityb (95% CI) PPV NPV
Intra-amniotic infection
 Plasma IL-6 (pg/mL) 0.76 ± 0.07 0.63–0.89 4.8 75.0 (50.1–93.2) 75.6 (47.6–92.7) 24.0 96.8
 AF IL-6 (ng/mL) 0.98 ± 0.01c 0.96–1.00 3.6 100 (79.4–100.0)d 92.4 (87.0–96.0)d 57.1 100
 Serum CRP (mg/L) 0.81 ± 0.06 0.69–0.93 11.2 62.5 (35.4–84.8) 86.0 (80.0–91.0)e 31.3 95.7
 Cervical length (mm) 0.66 ± 0.06 0.55–0.77 20.6 62.5 (35.4–84.8) 65.0 (57.0–72.4)f 15.4 94.4
Imminent preterm delivery
 Plasma IL-6 (pg/mL) 0.77 ± 0.06 0.66–0.88 4.8 73.1 (52.2–88.4) 78.2 (70.7–84.6) 37.3 94.3
 AF IL-6 (ng/mL) 0.74 ± 0.05 0.64–0.85 1.5 61.5 (40.6–79.8) 78.2 (70.7–84.6) 33.3 92.0
 Serum CRP (mg/L) 0.68 ± 0.06 0.57–0.79 3.5 88.5 (69.9–97.6) 51.0 (42.7–59.4)d 24.2 96.2
 Cervical length (mm) 0.81 ± 0.05 0.72–0.90 20.0 76.9 (56.4–91.0) 71.4 (63.4–78.6) 32.3 94.6
  1. SE standard error; ROC receiver-operating characteristic, CI confidence interval, PPV positive predictive value, NPV negative predictive value; IL-6 interleukin-6, AF amniotic fluid, CRP C-reactive protein
  2. aCut-off values corresponding to the highest sum of sensitivity and specificity
  3. bValues are given as % (95% CI)
  4. cP < 0.001 compared to plasma IL-6 by the method of DeLong et al.
  5. dP < 0.001 compared to plasma IL-6 by McNemar’s test
  6. eP < 0.01 compared to plasma IL-6 by McNemar’s test
  7. fP < 0.05 compared to plasma IL-6 by McNemar’s test