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Table 4 Unadjusted and adjusted odds ratios for the development of gestational hypertension after exposure to antidepressant in the sensitivity analysis for the duration of gestation

From: Antidepressant use during pregnancy and the risk of developing gestational hypertension: a retrospective cohort study

Outcome 37 weeks 35 weeks
Unadjusted OR (95% CI) Adjusted OR (95% CI)a P-Value Unadjusted OR (95% CI) Adjusted OR (95% CI)a P-value
Antidepressant use
 No exposure
 Exposure 2.13 (1.36–3.32) 2.17 (1.37–3,44) .001 2.14 (1.34–3.42) 2.21 (1.37–3.58) .001
Type of antidepressant
 TCAs 1.92 (0.60–6.11) 1,98 (0.62–6.34) .252 2.20 (0.69–7.02) 2,31 (0.72–7.44) .161
 SSRIs 2.15 (1.29–3.57) 2.14 (1.28–3.60) .004 2.08 (1.21–3.57) 2.09 (1.20–3.64) .009
 MAOI
 RIMA
 Other 1.62 (0.39–6.63) 1.64 (0.40–6.78) .495 1.92 (0.47–7.92) 1.98 (0.48–8.23) .348
DDD
  ≤ 30 0.72 (0.18–2.90) 0,79 (0.19–3.23) .744 1.35 (0.43–4.27) 1.45 (0.46–4.62) .529
  ≥ 30 2.68 (1.68–4.29) 2.65 (1.63–4.29) <.001 2.41 (1.45–4.01) 2.44 (1.45–4.11) .001
DDD SSRIs
  ≤ 30 0.54 (0.07–3.90) 0.59 (0.08–4.31) .607 1.48 (0.36–6.06) 1.57 (0.38–6.49) .532
  ≥ 30 2.68 (1.68–4.29) 2.65 (1.63–4.28) .001 2,23 (1.24–3.99) 2.20 (1.21–3.98) .010
Period
 0–10 weeks 2.21 (1.40–3.49) 2.25 (1.41–3.61) .001 2.32 (1.43–3.74) 2.38 (1.46–3.90) .001
 11–20 weeks 2.48 (1.47–4.20) 2.48 (1.45–4.26) .001 2.42 (1.43–4.10) 2.44 (1.43–4.20) .001
 0–10 weeks only 1.56 (0.69–3.54) 1.64 (0.71–3.74) .242 1.50 (0.55–4.07) 1.59 (0.58–4.35) .365
 Both periods (0–20 weeks) 2.69 (1.56–4.64) 2,69 (1.53–4.68) .001 2.74 (1.59–4.73) 2.75 (1.58–4.82) <.001
Maternal age
 15–19
 20–24 1.31 (0.18–9.68) .790 1.77 (0.24–13.15) .579
 25–29 1.97 (0.80–4.86) .143 1.75 (0.64–4.78) .278
 30–34 2,88 (1.49–5.53) .002 2.89 (1.45–5.75) .003
 34–39 1.29 (0.40–4.17) .666 1.37 (0.42–4.41) .600
 40+ 1.30 (0.29–5.73) .729 1.30 (0.29–5.73)   .729
  1. OR odds ratio, CI confidence interval, TCAs tricyclic antidepressants, SSRIs selective serotonin reuptake inhibitors, MAOI non-selective monoamine oxidase inhibitors, RIMA reversible inhibitors monoamine oxidase A, DDD defined daily dose
  2. aAdjusted for maternal age and medications use during pregnancy i.e. prescriptions of benzodiazepines and antibiotics