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Table 4 Associationsa between common carotid artery intima-media thickness, physical predictors, and significant metabolic predictors

From: Common carotid artery intima-media thickness increases throughout the pregnancy cycle: a prospective cohort study

Predictor Unadjusted   Model 1b Model 2b Model 3b
  ß (SE) P-value ß (SE) P-value ß (SE) P-value ß (SE) P-value
Trimester 1 Ref   Ref   Ref   Ref  
Trimester 2 0.001 (.01) 0.89 0.001 (.01) 0.89 0.002 (.01) 0.85 0.007 (.01) 0.56
Trimester 3 0.013 (.01) 0.24 0.013 (.01) 0.24 0.009 (.01) 0.43 0.022 (.02) 0.22
Postpartum 0.027 (.01)c 0.02 0.027 (.01) c 0.02 0.026 (.01)cd 0.03 0.031 (.01)c 0.01
Age (yr)    0.004 (.00) 0.03 0.004 (.00) 0.02 0.003 (.00) 0.08
Pre-pregnancy BMI (kg/m2)    −0.001 (.00) 0.78 −0.002 (.00) 0.45 0.000 (.00) 0.93
SBP (mm Hg)      0.001 (.00) 0.08   
Weight (kg)        −0.000 (.00) 0.66
Predictor Model 4b Model 5 b Model 6b Model 7b
  ß (SE) P-value ß (SE) P-value ß (SE) P-value ß (SE) P-value
Trimester 1 Ref   Ref   Ref   Ref  
Trimester 2 0.016 (.01) 0.19 0.018 (.01) 0.17 0.007 (.01) 0.59 0.009 (.01) 0.51
Trimester 3 0.042 (.02)c 0.04 0.041 (.02)c 0.046 0.027 (.02) 0.19 0.033 (.02)c 0.13
Postpartum 0.036 (.01)d 0.003 0.035 (.01)d 0.005 0.034 (.01)c 0.006 0.027 (.01)d 0.03
Age (years) 0.002 (.00) 0.11 0.003 (.00) 0.07 0.003 (.002) 0.05 0.003 (.00) 0.12
Pre-pregnancy BMI (kg/m2) −0.001 (.00) 0.70 −0.002 (.00) 0.35 −0.004 (.00) 0.15 −0.002 (.00) 0.55
Weight change (kg) −0.002 (.00) 0.13 −0.002 (.00) 0.07 −0.002 (.00) 0.06 −0.002 (.00) 0.08
SBP (mmHg)    0.001 (.00) 0.04 0.001 (.00) 0.04 0.001 (.00) 0.03
Inter-adventitial diameter      0.026 (.01) 0.02 0.017 (.01) 0.17
Log HOMA-IR        −0.028 (.01) 0.03
  1. aLinear mixed models
  2. bModel 1: Adjusted for age & pre-pregnancy BMI. Model 2: Model 1 plus SBP. Model 3: Model 1 plus weight. Model 4: Model 1 plus weight change. Model 5: Model 1 plus SBP and weight change. Model 6: Model 5 plus inter-adventitial diameter. Model 7: Model 6 plus HOMA-IR
  3. cDifferent from second trimester at p < .05. dDifferent from third trimester at p < .05
  4. BMI is body mass index. SBP is systolic blood pressure. Weight change is from pre-pregnancy weight. β represents change in millimeters