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Table 5 Maternal characteristics and clinical risk factors associated with early- and late-onset preeclampsia

From: Population-based trends and risk factors of early- and late-onset preeclampsia in Taiwan 2001–2014

  Early onset preeclampsia Late onset preeclampsia Ratio of Relative risk (95%CI) P Value
Crude Relative risk (95%CI) P Value Adjusted Relative risk (95%CI)a P Value Crude Relative risk (95%CI) P Value Adjusted Relative risk (95%CI)a P Value   
Age at delivery
 15–24 Reference   Reference   Reference   Reference   Reference  
 25–34 1.79 (1.69–1.90) < 0.01* 1.73 (1.63-1.84) < 0.01* 1.33 (1.27-1.39) < 0.01* 1.36 (1.30-1.43) < 0.01* 1.27 (1.78-1.37) < 0.01*
 35–55 3.84 (3.60–4.10) < 0.01* 3.21 (2.99-3.44) < 0.01* 2.31 (2.19-2.42) < 0.01* 2.28 (2.16-2.40) < 0.01* 1.41 (1.29-1.54) < 0.01*
Number of prior 20 weeks births (parity)
 0 1.06 (1.02–1.09) < 0.01* 1.39 (1.34-1.44) < 0.01* 1.65 (1.59-1.70) < 0.01* 1.95 (1.89-2.02) < 0.01* 0.71 (0.68-0.75) < 0.01*
  ≥ 1 Reference   Reference   Reference   Reference   Reference  
Acute Coronary syndromeb
 No Reference   Reference   Reference   Reference   Reference  
 Yes 2.59 (2.04–3.28) < 0.01* 1 (0.78-1.30) 0.98 1.45 (1.11–1.90) < 0.01* 0.77 (0.58-1.02) 0.07 1.3 (0.89–1.90) 0.09
Chronic ischemic heart disease
 No Reference   Reference   Reference   Reference   Reference  
 Yes 3.44 (2.83–4.17) < 0.01* 0.84 (0.68-1.04) 0.11 2.45 (2.02–2.98) < 0.01* 0.92 (0.74-1.14) 0.45 0.91 (0.67–1.24) 0.28
Stroke
 No Reference   Reference   Reference   Reference   Reference  
 Yes 2.96 (2.37–3.68) < 0.01* 1.33 (1.05-1.68) 0.02* 2.07 (1.67-2.58) < 0.01* 1.28 (1.02-1.61) 0.03* 1.04 (0.75-1.44) 0.4
Diabetes mellitus
 No Reference   Reference   Reference   Reference   Reference  
 Yes 5.34 (4.91–5.81) < 0.01* 1.9 (1.71-2.10) < 0.01* 3.76 (3.46-4.08) < 0.01* 2.03 (1.85-2.23) < 0.01* 0.94 (0.82-1.08) 0.19
Chronic hypertension
 No Reference   Reference   Reference   Reference   Reference  
 Yes 22.73 (21.5–24.0) < 0.01* 16.8 (15.7-18.0) < 0.01* 12.21 (11.5-13.0) < 0.01* 9.85 (9.19-10.6) < 0.01* 1.71 (1.55-1.88) < 0.01*
Hyperthyroidism
 No Reference   Reference   Reference   Reference   Reference  
 Yes 1.68 (1.53–1.83) < 0.01* 1.18 (1.07-1.29) < 0.01* 1.48 (1.36-1.60) < 0.01* 1.21 (1.12-1.32) < 0.01* 0.98 (0.86-1.10) 0.34
  1. aAdjusted Relative risk: adjusted for with age at delivery, income, urbanization, parity, acute coronary syndrome, chronic ischemic heart disease, stroke, diabetes mellitus, chronic hypertension and hyperthyroidism
  2. bAcute Coronary syndrome included myocardial infarction and unstable angina
  3. *P < 0.05