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Table 3 Diagnostic performance of each analyte to predict <10th and < 3rd centile infants, and preeclampsia

From: Assessing the sensitivity of placental growth factor and soluble fms-like tyrosine kinase 1 at 36 weeks’ gestation to predict small-for-gestational-age infants or late-onset preeclampsia: a prospective nested case-control study

Outcome Analyte and cut-point Sensitivity Specificity PPV NPV
Birthweight < 10th centile (All SGA) sFlt-1 > 4570 pg/ml 19.6% [12.4–28.6%] 89.9% [84.9–93.6%] 18.0% [11.1–27.9%] 90.8% [89.8–91.6%]
PlGF < 117.3 pg/ml 28.8% [20.4–38.6%] 89.5% [84.6–93.3%] 24.2% [16.3–34.5%] 91.6% [90.5–92.5%]
sFlt-1:PlGF > 33.4 26.5% [18.2–36.1%] 89.9% [84.9–93.6%] 22.9% [15.0–33.2%] 91.5% [90.5–92.4%]
Birthweight < 10th centile (SGA only) sFlt-1 > 4570 pg/ml 16.8% [9.9–25.9%] 89.9% [84.9–93.6%] 14.8% [8.7–24.2%] 91.1% [90.3–91.9%]
PlGF < 117.3 pg/ml 24.7% [16.5–34.5%] 89.5% [84.6–93.3%] 20.2% [13.0–30.0%] 91.7% [90.7–92.6%]
sFlt-1:PlGF > 33.4 22.1% [14.2–31.8%] 89.9% [84.9–93.6%] 18.6% [11.6–28.5%] 91.7% [90.7–92.5%]
Birthweight < 3rd centile (All SGA) sFlt-1 > 4570 pg/ml 21.4% [8.3–41.0%] 87.5% [83.1–91.2%] 4.7% [2.2–9.7%] 97.5% [96.9–97.9%]
PlGF < 117.3 pg/ml 32.1% [15.9–52.4%] 85.0% [80.3–88.9%] 5.8% [3.3–10.1%] 97.8% [97.1–98.3%]
sFlt-1:PlGF > 33.4 28.6% [13.2–48.7%] 85.8% [81.1–89.6%] 5.5% [2.9–10.0%] 97.7% [97.0–98.1%]
Birthweight < 3rd centile (SGA only) sFlt-1 > 4570 pg/ml 22.2% [8.6–42.3%] 88.7% [84.4–92.2%] 5.2% [2.4–10.7%] 97.6% [97.1–98.1%]
PlGF < 117.3 pg/ml 29.6% [13.8–50.2%] 86.4% [81.9–90.2%] 5.7% [3.1–10.4%] 97.8% [97.2–98.3%]
sFlt-1:PlGF > 33.4 25.9% [11.1–46.3%] 87.3% [82.7–91.0%] 5.4% [2.7–10.3%] 97.7% [97.1–98.2%]
Preeclampsia sFlt-1 > 4570 pg/ml 56.4% [39.6–72.2%] 89.9% [84.9–93.6%] 18.4% [12.1–26.9%] 98.1% [97.3–98.6%]
PlGF < 117.3 pg/ml 64.1% [47.2–78.8%] 89.5% [84.6–93.3%] 19.9% [13.6–28.2%] 98.4% [97.6–98.9%]
sFlt-1:PlGF > 33.4 69.2% [52.4–83.0%] 89.9% [84.9–93.6%] 21.7% [14.9–30.4%] 98.6% [97.8–99.1%]
  1. Data presented with [95% Confidence Interval]. *determined by a false positive rate of 10% in the birthweight ≥10th centile and no preeclampsia control group. “All SGA” = Cases of SGA fetuses including cases with co-existent preeclampsia; “SGA only” = Cases of SGA fetuses with cases of co-existant preeclampisa excluded; NPV Negative Predictive value, pg/ml = pictogram/millilitre, PlGF placental growth factor, PPV Positive Predictive Value, sFlt-1 soluble fms-like tyrosine kinase-1, SGA small-for-gestational-age