- Research article
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Adjunct clinical interventions that influence vaginal birth after cesarean rates: systematic review
BMC Pregnancy and Childbirthvolume 18, Article number: 452 (2018)
Rates of cesarean deliveries have been increasing, and contributes to the rising number of elective cesarean deliveries in subsequent pregnancies with associated maternal and neonatal risks. Multiple guidelines recommend that women be offered a trial of labor after a cesarean (TOLAC). The objective of the study is to systematically review the literature on adjunct clinical interventions that influence vaginal birth after cesarean (VBAC) rates.
We searched Ovid Medline, Ovid Embase, Wiley Cochrane Library, CINAHL via EBSCOhost; and Ovid PsycINFO. Additional studies were identified by searching for clinical trial records, conference proceedings and dissertations. Limits were applied for language (English and French) and year of publication (1985 to present). Two reviewers independently screened comparative studies (randomized or non-randomized controlled trials, and observational designs) according to a priori eligibility criteria: women with prior cesarean sections; any adjunct clinical intervention or exposure intended to increase the VBAC rate; any comparator; and, outcomes reporting changes in TOLAC or VBAC rates. One reviewer extracted data and a second reviewer verified for accuracy. Two reviewers independently conducted methodological quality assessments using the Mixed Methods Appraisal Tool (MMAT).
Twenty-three studies of overall moderate to good methodological quality examined adjunct clinical interventions affecting TOLAC and/or VBAC rates: system-level interventions (three studies), provider-level interventions (three studies), guidelines or information for providers (seven studies), provider characteristics (four studies), and patient-level interventions (six studies). Provider-level interventions (opinion leader education, laborist, and obstetrician second opinion for cesarean sections) and provider characteristics (midwifery antenatal care, physicians on night float call schedules, and deliveries by family physicians) were associated with increased rates of VBAC. Few studies employing heterogeneous designs, sample sizes, interventions and comparators limited confidence in the effects. Studies of system-level and patient-level interventions, and guidelines/information for providers reported mixed findings.
Limited evidence indicates some provider-level interventions and provider characteristics may increase rates of attempted and successful TOLACs and/or VBACs, whereas other adjunct clinical interventions such as system-level interventions, patient-level interventions, and guidelines/information for healthcare providers show mixed findings.
A cesarean delivery is the most common surgery in Canada, with one of the main contributors being an elective cesarean delivery in subsequent pregnancies [1, 2]. Canadian cesarean delivery rates have increased from 18.7% in 1997 to 27.5% in 2014  and continue to increase globally,  the result of an interplay of multiple factors including, but not limited to, shifting clinical environments, provider and patient preferences, and changing maternal demographics (e.g., obesity, chronic disease prevalence and advanced age) [5,6,7,8,9]. These factors can lead to higher-risk and more complex pregnancies and deliveries and an increased likelihood of a cesarean delivery [10, 11].
Depending on the etiology or indication, a cesarean delivery contributes to short- and long-term risks for both mother and infant [12, 13]. The Society of Obstetricians and Gynaecologists of Canada (SOGC) recommends that a trial of labor be offered to women with one previous transverse low-segment cesarean section . A woman’s willingness to undergo a trial of labor after cesarean (TOLAC) may be influenced by a multitude of factors . While a vaginal birth after a cesarean (VBAC) may be desired by some women, the patient-level benefits associated with a VBAC from avoiding major abdominal surgery and risk of complications in future pregnancies must be weighed against the potential for serious harms such as a failed TOLAC and subsequent maternal and neonatal morbidity including an unplanned repeat cesarean delivery . For women with more than one previous cesarean delivery, a VBAC is likely to be successful, but with an estimated higher risk of uterine rupture (0.2 to 1.5% with a transverse uterine incision, 1.0 to 1.6% with a low-vertical uterine incision) . This SOGC statement is consistent with recommendations from the American College of Obstetrics and Gynecology (ACOG) [16, 17].
This systematic review aimed to evaluate adjunct clinical interventions that could be directed at or used by patients, families, healthcare providers, and hospitals/health systems to influence the uptake and success of VBAC.
A research librarian searched the following databases in May 2017: Ovid Medline (1946-), Ovid Embase (1980-), Wiley Cochrane Library (inception-), CINAHL via EBSCOhost (1937-) and Ovid PsycINFO (1806-). Limits were applied for language (English and French) and publication year (1985). The search strategy used the Conference Proceedings Citation Indexes (Clarivate Analytics) and hand-searched meeting abstracts from the past 2 years from the following associations: The Society for Maternal-Fetal Medicine (SMFM), the Society of Obstetricians and Gynaecologists of Canada (SOGC), and the American Congress of Obstetricians and Gynecologists. Finally, we searched ClinicalTrials.gov and ProQuest Dissertations & Theses Global (1861-). Reference lists of relevant systematic reviews were reviewed for potentially eligible studies. The detailed search strategy is in Additional file 1: Appendix 1.
The study population was women who had a previous cesarean delivery including women with more than one prior cesarean delivery. Births attended by any healthcare provider (e.g., family physician, midwife, obstetrician/gynecologist) were eligible. Any intervention or exposure that was intended to effect a change in the VBAC rate among women with a prior cesarean delivery was eligible for inclusion. To be eligible, studies had to report on at least one of the outcomes of interest to the review: the primary outcome was change(s) in VBAC rates; secondary outcomes included TOLAC rates, or where reported, rates of successful VBAC among women undergoing a TOLAC. Studies that examined deliveries in any setting (e.g., hospitals, primary care centers, birthing units, home births) were eligible. All study designs (randomized [RCT] and non-randomized controlled trials [NRCT], and observational studies) with a comparison group were eligible for inclusion.
Studies were not considered eligible if: all women had three or more prior cesareans; multiple births of three or more fetuses were explicitly included; there was an absence of an exposure or intervention, or an inappropriate exposure/intervention was used (e.g., ethnicity, socioeconomic status, insurance status, physician traits, malpractice premiums); there was absence of a comparator, or an inappropriate comparator was used (e.g., no data for comparison groups in before-after study designs, women without a previous cesarean delivery); VBAC rates or change were not reported; or, they were not primary research (e.g., letter, editorial, commentary). Systematic reviews were not included; reference lists therein were screened for potentially relevant studies.
Two reviewers (CJ and AW) independently screened titles and abstracts using a priori eligibility criteria. Full texts of potentially relevant publications were retrieved and independently reviewed in duplicate for inclusion; disagreements were resolved through discussion or third-reviewer consultation.
One reviewer extracted data and another verified data from each included study using a pre-specified and piloted form. Data were extracted for relevant study characteristics (design features), population (number of previous cesarean deliveries, parity), intervention, comparator, outcome (TOLAC rate [the number of women with a previous cesarean delivery who attempt a vaginal delivery] and VBAC rate [the number of women with a previous cesarean delivery who undergo a successful vaginal delivery]), funding source, and setting.
Intention-to-treat results were extracted from individual studies whenever possible. For dichotomous data on rates of TOLAC and VBAC, we reported counts or proportions, and sample size, by study arm. Results of statistical tests (e.g., p-values) or summary statistics (e.g., odds ratio [OR], risk ratio [RR], with confidence intervals [CI]) were extracted whenever these were reported within the studies.
Assessment of methodological quality
Two reviewers independently assessed the methodological quality of included studies; disagreements were resolved via consensus. All studies were assessed using the Mixed Methods Appraisal Tool (MMAT ), a tool designed for systematic reviews that include multiple study designs.
Due to heterogeneity of interventions and comparators, pooling of data across studies for a meta-analysis was not appropriate; therefore, results were described narratively.
Assessment of overall quality of evidence
Data from studies were not pooled for summary effect estimates; therefore, assessment of the quality of the body of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE ) was not conducted.
The literature search identified 5269 unique records eligible for inclusion. After screening titles and abstracts, 305 potentially relevant articles were identified. Full text screening yielded 23 studies [22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44] included in the review. The screening process is illustrated in Fig. 1.
Studies published from 1987 to 2017 were conducted in the United States (13 studies; 57% [23,24,25,26,27, 30, 34, 35, 37,38,39, 42, 44]), Canada (three studies; 13% [28, 32, 36]), United Kingdom (three studies; 13% [33, 40, 41]), Australia (one study; 4% ), China (one study ), Portugal (one study; 4% ), and Taiwan (one study; 4% ). Funding was from non-industry sources (ten studies; 43% [25,26,27,28, 30, 32, 33, 36, 40, 42]), without funding (two studies; 9% [22, 43]), or was not reported (11 studies; 48% [23, 24, 29, 31, 34, 35, 37,38,39, 41, 44]). The sample size varied depending on unit of reporting, with a mean of 1276 women (14 studies; [23, 25,26,27,28,29,30, 32, 33, 36, 40,41,42,43] range 96 to 4732) or 306,097 deliveries (nine studies; [22, 24, 31, 34, 35, 37,38,39, 44] range 5308 to 1,260,186).
The majority of studies included women (or records of women) who delivered in hospital (20 studies; [23,24,25, 27,28,29,30,31,32,33,34, 36,37,38,39,40,41,42,43,44] 87%), health clinics (one study;  4%), and in multiple settings including hospitals and at home (two studies; [22, 35] 9%). Of the 12 studies [23, 25, 26, 28, 29, 32, 36, 39, 40, 42,43,44] (52%) that reported maternal age, a wide range of women (18 years and younger to 40 years and older) were represented. Studies explicitly reported including women with 1 prior cesarean delivery (six studies [26, 28, 29, 40,41,42]), one or two prior cesarean deliveries (one study ), and at least one prior cesarean delivery (three studies [23, 33, 36]); the latter three included some women with three or more prior cesarean deliveries.
While all studies reported the proportion of women who had a VBAC, about half (13 studies; [25, 27,28,29,30, 32, 34, 36, 37, 40,41,42, 44] 57%) provided comparative proportions of women who had a TOLAC.
Most studies were cohorts (16 studies; one non-concurrent cohort contained 3-arms [22, 23, 25, 29,30,31, 34,35,36,37,38,39,40,41,42, 44]); a small proportion were RCTs (five studies; three trials contained three-arms [26, 28, 32, 33, 43]), before-after (one study ), and cross-sectional (one study ).
Table 1 summarizes the strategies/outcome themes among the studies. Tables 2, 3, 4, 5 and 6 summarize the included studies by categories of interventions. Additional file 1: Appendix 2 details characteristics of the individual studies.
Methodological quality of included studies
All of the studies received a score for having a clear research question or objective, and for collecting data that addressed the intended research question.
Of the five RCTs, four (80%) [26, 28, 32, 33] described the randomization process clearly, but only one (20%)  clearly described allocation concealment or blinding. Four (80%) RCTs [28, 32, 33, 43] had complete outcome data for at least 80% of the participants. Three (60%) RCTs [26, 28, 33] had a withdrawal or drop-out rate of less than 20%. Overall, one (25%) RCT  met all of the criteria (four out of four stars).
The majority (16 studies; 89%) [22,23,24, 27, 29,30,31, 35,36,37,38,39,40,41,42, 44] of the non-randomized controlled studies recruited participants or organizations in a way that minimized selection bias. Most (17 studies; 94%) [22,23,24,25, 27, 30, 31, 34,35,36,37,38,39,40,41,42, 44] studies used appropriate measurements for the interventions/exposures and outcomes, and used interventions that did not present potential contamination between groups. Only seven (39%) studies [23, 24, 27, 39, 40, 42, 44] accounted for important differences between groups, or controlled for such differences in the data analysis. Many studies (n = 16; 89%) [22,23,24,25, 27, 29, 31, 34,35,36,37,38,39,40, 42, 44] had complete outcome data for at least 80% of the participants, or an acceptable response or follow-up rate (i.e., 60% or above). Overall, seven (39%) [23, 24, 27, 39, 40, 42, 44] studies scored four stars (out of four).
TOLAC and VBAC rates
Three studies [22, 24, 31] examined system-level interventions (Table 2). One non-concurrent cohort compared deliveries in continental Portugal before and after a concerted action to reduce cesarean section rates based on transmission and training of healthcare professionals as well as targeted cesarean delivery rates for contingency-based hospital funding, and found an increase in the VBAC rate from 16.4% (13,399 of 81,750 VBACs) in 2009 to 32.8% (16,859 of 51,478 VBACs) in 2014 (p < 0.001) . Another non-concurrent cohort of deliveries at a tertiary hospital in Taiwan found that rates of vaginal deliveries in women with previous cesarean deliveries increased (from 4.8% [38 of 800 deliveries] to 12.2% [231 of 1887 deliveries]) after implementation of direct government funding of hospitals from 2002 to 2005 (rate ratio 0.82, 95% CI 0.74–0.90, p = 0.0001), but the rate did not improve further (from 12.2% [231 of 1887 deliveries] to 11.4% [298 of 2621 deliveries]) with the additional employment of a hospital-based post-operative peer review and audit strategy from 2005 to 2010 (rate ratio 0.98, 95% CI 0.96–0.99, p = 0.0003) . One study compared peer reviewed with non-reviewed hospitals (45 [mean 1430 deliveries in 1988 and mean 1503 deliveries in 1993] versus 120 hospitals [mean 1720 deliveries in 1988 and 1993]), and found that VBAC rates increased between the years by 14.6 and 12.7% (reviewed and non-reviewed hospitals, respectively), although the difference between reviewed and non-reviewed hospitals was not statistically significant .
Three studies examined provider-level interventions [27, 32, 34] (Table 3). One RCT of community hospitals compared opinion leader education (739 women from four hospitals) and audit and feedback (524 women from four hospitals) to mailed guideline recommendations (1233 women from eight hospitals), and found that women were more likely to attempt a TOLAC when delivering in obstetric departments with influential opinion leaders (38.2%) compared to units with audit and feedback (21.4%) or mailed practice guidelines (28.3%) (46% higher in the opinion leaders group versus the other groups, p = 0.007) . Women were also more likely to have VBACs in the opinion leader group (25.3%) compared with the audit and feedback (11.8%) and guideline groups (14.5%) (85% higher in the opinion leaders group versus the other groups, p = 0.003) . A cross-sectional study found that a higher proportion of women with prior cesarean delivery had a TOLAC in hospitals employing laborists (356 of 2621 women; 13.6%) compared with hospitals without laborists (201 of 2111 women; 9.5%) . A higher rate of successful VBACs occurred in the same group, however the result was not statistically significant (9.7% versus 6.5%; adjusted odds ratio (aOR) 1.10, 95% CI 0.82–1.47, p = 0.5417) . A non-concurrent cohort comparing deliveries in 1985 with deliveries in 1986 to 1991 after the implementation of a hospital initiative utilizing a second opinion by an obstetrician for primary and repeat cesarean deliveries, found increased rates of TOLAC (45.0% versus range 68.4 to 91.3%, pre- versus post-intervention, respectively) and VBAC (23.8% versus range 54.9 to 67.4%, pre- versus post-intervention, respectively) .
Four studies [36, 40, 42, 43] examined the effect of provider characteristics on VBAC rates (Table 4). A small RCT of women in labor compared midwifery care (n = 48) with standard maternity care (n = 48); the authors reported a higher proportion of VBAC among women receiving continuous midwifery care from the antenatal to postnatal period (87.5% versus 66.7% of women, p < 0.05) . Another study examined midwifery care and found that among women with one previous cesarean delivery, there was a higher rate of attempted VBACs in the post-intervention (midwifery-led antenatal care; 153 of 196 women; 78.1%) compared with the pre-intervention group (traditional obstetrician-led antenatal care; 143 of 209 women; 68.4%) . More VBACs occurred in the group who received care from a midwife in 2011 (120 of 196 women; 61.2%) than among women who received obstetrician-led antenatal care in 2008 (98 of 209 women; 46.9%, aOR 1.79; 95% CI 1.17–2.75, p < 0.05). One retrospective cohort compared physicians with a traditional call schedule (946 women) with physicians on a night float call schedule (556 women); eligible women were more likely to undergo a TOLAC when delivered by physicians on a night float call system (OR 2.50, 95% CI 1.96–3.20, p < 0.001) and the effect persisted when the groups were adjusted for body-mass index (BMI), gestational age (GA) and physician (aOR 2.64, 95% CI 1.65–4.25, p < 0.001) . A cross-sectional study of women with at least one previous cesarean delivery with a singleton delivery compared women delivered by an obstetrician (n = 3493) with women delivered by a family physician (n = 201), and found that more TOLACs occurred in the latter than the former group (81.1% versus 50.6%, p < 0.001) as well as VBACs (61.7% versus 32.5%) .
Guidelines or information for providers
Seven non-concurrent cohort studies in the US [23, 30, 35, 37,38,39, 44] examined VBAC rates before and after guidelines or information for providers were implemented (Table 5). Kosecoff et al. compared VBAC rates in 1979 and 1980 (35 and 64 women, respectively) before the National Institutes of Health conference recommendations, with rates in 1981 to 1982 (70 women); a greater proportion of women had a TOLAC (5.7 and 11.0% pre- versus 28.6% post-recommendations) and a VBAC (5.7 and 6.3% pre- versus 15.7% post-recommendations) after the conference recommendations (adjusted positive linear trend of 2.4 [5.8%] for TOLAC and 2.1 [4.5%] for VBAC) . Another study comparing before (1987–1988) and after (1988–1991) the ACOG practice guidelines were implemented reported that VBAC rates increased by 5.6 percentage points as a result of the guideline and its information dissemination . Pinette et al. also compared rates of VBAC before (1998) and after (1999–2001) ACOG guidelines were revised to require the presence of surgical personnel throughout a trial of labour, and found a marked decline in hospital VBAC data (relative risk 3.5, 95% CI 3.1–4.2, p < 0.01), citing factors such as patient refusal post-counselling, inability of institutions to meet requirements, and lack of support from the obstetric service . Zweifler et al. examined the effect of the ACOG revision to provide immediate cesarean capability (1996 to 1999 versus 2000 to 2002, before versus after, respectively) and found that there were comparatively fewer TOLACs (24.0% before versus 13.5% after guideline revision, p < 0.001) and successful VBACs among women with TOLACs (82.8% [41,961 of 50,670 deliveries] before versus 81.8% [19,273 of 23,573 deliveries] after guideline revision) . In a study focused on the impact of state-legislated practice guidelines, the authors reported that dissemination alone did not significantly increase the VBAC rate (7151 of 23,142 deliveries; 30.9% post-guideline in 1993) compared with the years leading up to the change (4816 of 22,091 deliveries [21.8%] in 1990; 5540 of 21,461 deliveries [25.6%] in 1991; and, 6133 of 22,970 deliveries [26.7%] in 1992) . A study compared intrapartum management of women with prior cesareans before (1986–1987) and after (1988–1989) hospital guideline changes incorporated centralized decision-making, and found that rates of TOLAC increased from 31.7% (139 out of 438 women in 1986) to 84.0% (487 out of 580 women in 1989; p < 0.0001), and that the proportion of these women with subsequent VBACs also increased (from 64.7% [90 out of 139 women in 1986] to 82.8% [403 out of 487 women in 1989, p < 0.0001) . Bellows et al. examined changes to hospital policies for TOLAC eligibility and labor induction guidelines; the authors reported that while the “overall VBAC rate” (number of women with a prior cesarean who had a VBAC) increased (26.0% pre- versus 33.0% post-guidelines, p < 0.0001), the “VBAC rate” (number of women who underwent a TOLAC and had a successful VBAC) was unchanged (78.9% pre- versus 78.1% post-guidelines, p = 0.75) .
Six studies [25, 26, 28, 29, 33, 41] examined patient-level interventions (Table 6). One RCT of women with a single previous low transverse cesarean delivery compared a verbal prenatal education program (641 women) with a written prenatal education program (634 women) and found no evidence of a clinically significant difference for TOLAC rate (72.5% versus 69.4%; relative risk 1.1, 95% CI 1.0–1.1) or VBAC rate (52.9% versus 48.9%; relative risk 1.1, 95% CI 1.0–1.2) . Another RCT compared two interventions (decision analysis aid [235 women] and information program [241 women]) with usual care (239 women), reporting the highest rate of VBAC in the decision analysis group (37.4% versus 29.2% versus 30.3%, decision analysis versus information program versus usual care, respectively; no significant differences between groups) and concluded that women who received any decision aid had greater knowledge and less anxiety than women receiving standard obstetric care . Another trial compared an evidence-based computerized decision aid (66 women) with evidence-based educational ACOG brochures (65 women) and reported that women experienced less decisional conflict in the former group compared with the latter, however, there was no significant difference in VBACs (41.0% versus 37.0%, p = 0.724) . A cohort study of patient satisfaction with mode of delivery found that women who received formal one-on-one antenatal counseling (n = 95) had comparatively higher rates of TOLAC (46.3% versus 38.5%) but lower rates of VBAC (27.4% versus 31.7%) than women who didn’t participate in VBAC counseling (n = 221) . A non-concurrent cohort of women with a single prior cesarean delivery presenting in their next pregnancy had a higher VBAC rate after the implementation of standardized consultant labor management with a dedicated antenatal clinic (27.0% versus 17.2%, p < 0.001) compared with women who received routine antenatal care with mode of birth counseling on an ad-hoc basis . Another cohort study reported higher rates of TOLAC (57.4% versus 42.0%, p = 0.02) and VBAC (31.4% versus 25.6%) among women who attended an obstetrician-led cesarean delivery education and antenatal session (n = 188) compared with women who chose not to attend the session (n = 78), although the authors concluded that the overall rate of successful vaginal deliveries among women who attempted VBAC was not influenced by the education session .
This systematic review of adjunct clinical interventions aimed at influencing the rate of VBACs identified 23 studies which suggest that some provider-level interventions (e.g. opinion leader education in hospitals, employing laborists as providers, and utilizing obstetrician ‘second opinion’ for all cesarean deliveries), and provider characteristics (i.e., midwifery-led antenatal care, physicians working a night call float schedule, and birth deliveries by a family physician) are associated with higher TOLAC and VBAC rates, while system-level interventions (i.e., education and training of healthcare providers, contingency-based funding for delivery rates, and peer review/audit), patient-level interventions (i.e., different modes of information delivery, and antenatal counseling for women) and provider guidelines/information report mixed findings. The significant study heterogeneity in research designs, interventions and outcomes did not allow for a meta-analysis to be completed.
Other systematic reviews of adjunct clinical interventions to increase VBAC rates have reported similar findings, although eligibility criteria among these reviews differed slightly from the present study. Catling-Paull et al.  examined non-clinical interventions (27 studies) and concluded that local guidelines, opinion leaders and individualized information for women can impact the uptake and/or success of VBAC. While the present study also found that opinion leaders increased VBACs, evidence from guidelines had conflicting findings and information for women did not show significant differences between groups. Lundgren et al.  evaluated clinician-centered interventions designed to increase VBAC rates (three studies) and concluded that educational strategies delivered by opinion leaders significantly increased VBAC rates, while external peer review and audit and feedback had no significant effect; the present review also found the impact of opinion leader education on VBACs. A systematic review of women-centered interventions to increase VBACs (three studies) concluded that while decision aids and information programs during pregnancy did not appear to affect the rate of VBAC, they reduced women’s decisional conflict and increased their knowledge regarding birth options . The present study echoed the findings that information for women was associated with increased VBAC in one study but without significant difference in two studies.
Strengths and limitations of study
A methodologically rigorous systematic review of the literature was undertaken to capture a broad range of studies of adjunct clinical interventions directed at increasing maternal VBAC rates. However, several factors limit our confidence in effects of interventions, such as inclusion of non-randomized study designs, small number of studies per intervention category, and inconsistent results across heterogeneous studies. Moreover, many studies did not report important maternal baseline characteristics in a consistent manner, including antenatal history (e.g., parity, number of previous cesarean deliveries and vaginal births, medical history/risk factors) or indications (e.g., age, gestational age, fetal risk factors).
Implications for practice
Based on the available evidence, attempts to increase vaginal births among women with prior cesareans need to incorporate different types of provider or provider-level interventions to achieve a greater likelihood of success. Hospitals that utilize the ‘influential opinion leader model’ to educate colleagues and patients can effect a behavior/clinical change by offering more women the opportunity of a VBAC. Staffing community hospitals with laborists may encourage more support for women to attempt a vaginal delivery. Requiring an expert second opinion prior to a cesarean may decrease the proportion of women who undergo cesarean deliveries (exclusive of those performed for acute emergencies) through counseling, thereby increasing choice and the number of attempted VBACs. Low risk maternity providers (e.g., midwives, family physicians) or the continuity of midwifery care may provide women with support and confidence to undergo a VBAC through a personalized and responsive approach. Overall, these are aligned with the SOGC recommendation that women be given the opportunity to consult with her obstetric care provider on the risks and benefits of TOLAC as well as awareness of availability of hospital resources for an elective cesarean section if indicated . Adoption of any strategy or intervention to increase rates of TOLAC and subsequent VBAC must carefully weigh the potential benefits against the possible risks for mother and baby.
As the scope of the current review was sufficiently broad, the authors did not search for studies that examined barriers to VBAC or factors related to women’s motivations, preferences or decision-making. Studies of clinicians’ and women’s perspectives may provide insight on system, provider-level, and patient-oriented factors that influence rates of attempted and successful VBAC [48, 49]. For example, a qualitative study examined barriers associated with the ACOG VBAC guidelines and found that fear of liability affected the willingness of midwives and obstetricians in offering VBAC . Other factors such as the continual presence of a physician, travel distance to a hospital that offers TOLAC (although 56% of California hospitals permit TOLAC, significantly fewer VBACs were actually carried out), and hospital policy for patient TOLAC eligibility presented as other systemic barriers restricting women’s access to a TOLAC . Additionally, there is a paucity of studies on supports intended to facilitate shared decision-making between women and their healthcare providers . Such evidence may provide context for effectiveness, acceptability and feasibility of interventions aimed at individual patients’ needs, decisions and satisfaction regarding mode of birth.
This ‘up-to-date’ systematic review evaluated adjunct clinical interventions directed at increasing the rate of vaginal delivery among women with a prior cesarean delivery and provides evidence that some provider-level interventions and provider characteristics are associated with higher maternal TOLAC and VBAC rates. Further research, using robust study designs with documentation of population characteristics, is needed to provide stronger outcome evidence for the use and effect of adjunct clinical interventions. Enhancing the woman’s education and her opportunity to consider and choose VBAC over a repeat cesarean delivery is an important clinical outcome and goal to examine in future research and reviews.
American College of Obstetrics and Gynecology
adjusted odds ratio
Body mass index
Grading of Recommendations Assessment, Development and Evaluation
Mixed Methods Appraisal Tool
Non-randomized clinical trial
Randomized clinical trial
The Society for Maternal-Fetal Medicine
The Society of Obstetricians and Gynaecologists of Canada
Trial of labor after cesarean
Vaginal birth after cesarean
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We would like to thank: Tara Landry, MLIS, for peer reviewing the search strategy; Ms. MacKinna Hauff for article retrieval; Dr. Allison Gates and Dr. Michelle Gates for assistance with the French translations.
This study was funded by the Maternal, Newborn, Child and Youth Strategic Clinical Network (MNCY SCN) of Alberta Health Services (AHS) and the Alberta Strategy for Patient-Oriented Research (SPOR) SUPPORT Unit Knowledge Translation Platform. The funders had no role in the design of the study, the collection, analysis or interpretation of data, the writing of the manuscript, or the decision to submit the article for publication.
Availability of data and materials
All data generated or analyzed during this study are included in this published article (and its supplementary information files).
Ethics approval and consent to participate
This is a systematic review of previously published data and as such does not require ethics approval.
Consent for publication
All authors declare funding from MNCY SCN of AHS and Alberta SPOR SUPPORT Unit KT Platform; LH, MS and RF are employed in part or whole by the Alberta SPOR SUPPORT KT Platform; LH was funded in part by a New Investigator Salary Award from CIHR; there are no other relationships or activities that could appear to have influenced the submitted work.
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Appendix 1. Search strategy. Appendix 2. Characteristics of included studies. Appendix 3. Methodological quality assessments of included studies. (PDF 424 kb)